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Regulation of p75 death signalling: how neurotransmitter- and neurotrophic- signals determine cell survival (2008–2011)

Abstract:
Nerve survival is dependent on trophic support in the form of growth factors and synaptic input, both of which promote recovery after nerve injury. The survival pathways activated by growth factors are generally well characterised, whereas survival signals activated by synaptic activity are largely unexplored. This proposal sims to discover how synaptic activity prevents nerve cell death by looking at how synaptic activity inhibits the processes active in dying nerve cells.
Grant type:
NHMRC Project Grant
Researchers:

  • Professor Elizabeth Coulson

    Head of School
    School of Biomedical Sciences
    Faculty of Medicine
    Head of School
    Faculty of Medicine
    Professor
    Queensland Brain Institute
    Professor and Professorial Research
    Queensland Brain Institute
    of Clem Jones Centre for Ageing and
    Clem Jones Centre for Ageing Dementia Research
    Queensland Brain Institute
    Head of School of Biomedical Scienc
    School of Biomedical Sciences
    Faculty of Medicine

  • Professor Pankaj Sah

    Institute Director
    Office of the Provost
    Institute Director
    Queensland Brain Institute
    Centre Director of The Asia-Pacific
    Asia-Pacific Centre for Neuromodulation
    Queensland Brain Institute
    Centre Director of The Science of L
    Science of Learning Centre
    Queensland Brain Institute

  • Professor Frederic Meunier

    Professor and Academic Senior Group
    Queensland Brain Institute
    of Clem Jones Centre for Ageing and
    Clem Jones Centre for Ageing Dementia Research
    Queensland Brain Institute
    of Clem Jones Centre for Ageing and
    Clem Jones Centre for Ageing Dementia Research
    Queensland Brain Institute
    Affiliate Professor of Institute fo
    Institute for Molecular Bioscience
Funded by:
National Health and Medical Research Council