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From structures to systems: A hierachical approach to understanding sub-cellular components. (2008–2010)

Abstract:
To truly understand fundamental processes within cells such as how membranes form, how processes such as membrane fission and fusion are regulated or how proteins self-assemble into functional complexes (micro machines) we must combine structural studies with predictive models that can accurately reproduce the dynamic properties of real systems. Our aim is to develop new hierarchical approaches for simulating biomolecular systems that integrate atomic level descriptions with more coarse-grained representations and to apply these approaches to provide a better understanding of membrane trafficking and other forms of emergent behaviour within cells.
Grant type:
ARC Discovery Projects
Researchers:

  • Professor Alan Mark

    Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliate of ARC COE for Innovation
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
    Affiliate of ARC COE in Quantum Bio
    ARC Centre of Excellence in Quantum Biotechnology
    Faculty of Science

  • Professor Brett Collins

    NHMRC Leadership Fellow - GL
    Institute for Molecular Bioscience
    NHMRC Leadership Fellow - GL
    Institute for Molecular Bioscience
    of Institute for Molecular Bioscien
    Institute for Molecular Bioscience
    Affiliate Professor of School of Bi
    School of Biomedical Sciences
    Faculty of Medicine
Funded by:
Australian Research Council