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Ex vivo production of neutrophils (2006–2009)

Abstract:
The aim of this project is to develop and validate a practical, cost efficient process for production of cord blood derived neutrophils for treatment of neutropenia. Neutropenic sepsis is a main cause of treatment related morbidity and mortality in dose intensive cancer therapy. Transfusion of neutrophils is a logical approach to preventing or treating neutropenic sepsis. However, the complicated logistics of neutrophil collection as well as the of repeated G-CSF mobilisation in normal blood donors cast doubt over random donor neutrophil transfusion as a routine procedure. At the completion of this project, we expect to have a process capable of producing from a single frozen cord blood unit, 5 full doses of functional and safe neutrophils.'',
Grant type:
ARC Linkage Projects
Researchers:
Funded by:
Australian Research Council