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Chemical mimics of bioactive protein surfaces (2006–2011)

Abstract:
Proteins are the key functional components that define life, ageing, disease and death. Their uses in medicine, science and industry are extremely limited by their complexity, high costs, chemical instability and low bioavailability. This program will develop new chemical technology for creating simpler, smaller, cheaper, more stable and more bioavailable molecules that can execute selected functions of proteins. The approach involves devising stable new molecular shapes to mimic structural components of proteins (helices, turns, strands, and combinations), and using them as tools to interrogate biological systems and to explore prospective applications as new pharmaceuticals, diagnostics, vaccines, and nanomaterials.
Grant type:
ARC Federation Fellowships
Researchers:

  • Professor David Fairlie

    NHMRC Leadership Fellow and Group L
    Institute for Molecular Bioscience
    NHMRC Leadership Fellow and Group L
    Institute for Molecular Bioscience
    Affiliate of ARC COE for Innovation
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
    of Institute for Molecular Bioscien
    Institute for Molecular Bioscience
Funded by:
Australian Research Council