How does heme regulate blood vessel formation in the brain? (2023–2026)
Abstract:
There are more than 600 kilometres of blood vessels in the brain, all of which are lined by tightly packed cells that
protect the brain from toxins. My research aims to investigate how these blood vessels are formed. This project
expects to reveal the role that a critical signalling molecule called heme plays in this fundamental biological
process. I will use cutting-edge structural biology and biophysical techniques to uncover the molecular
mechanisms that allow heme to enter cells and regulate blood vessel growth in the brain. The outcomes of this
research will enhance our understanding of the brain¿s core infrastructure and will contribute to an understanding
of how cerebral blood vessels grow and maintain integrity.