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Structure of the essential Commander protein trafficking complex (2024–2026)

Abstract:
This project aims to provide a fundamental understanding of the structure and function of Commander, a large protein complex that controls export and recycling of internalised receptors. Commander is highly conserved throughout evolution and is essential for maintaining the homeostasis of hundreds of transmembrane receptors required for cell function and survival, regulating processes as diverse as lipid metabolism and cell adhesion. Despite advances in the understanding of Commander function, little is known about how Commander is assembled and interacts with other essential proteins. This project will use multidisciplinary cellular and structural biology approaches to reveal the architecture of Commander at an atomic level.
Grant type:
ARC Discovery Projects
Researchers:

  • Professor Brett Collins

    NHMRC Leadership Fellow - GL
    Institute for Molecular Bioscience
    NHMRC Leadership Fellow - GL
    Institute for Molecular Bioscience
    of Institute for Molecular Bioscien
    Institute for Molecular Bioscience
    Affiliate Professor of School of Bi
    School of Biomedical Sciences
    Faculty of Medicine
Funded by:
Australian Research Council