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Fyn-STEP-Tau axis: the nanoscale mechanisms of synaptic plasticity (2024–2026)

Abstract:
This project investigates how brain cells use their molecular machinery to communicate with one another. At the heart of this process lies the synapses, the contact points that connect brain cells. This project will employ an innovative combination of quantitative microscopy techniques, gene knockout mouse models, and advanced computational and mathematical analyses to generate new knowledge on how a crucial set of proteins organises in space and time to regulate synaptic connectivity. This will provide significant benefits, including molecular-level insight into the inner workings of the brain and interdisciplinary training for students. The expected outcomes include a deeper understanding of brain functions, such as learning and memory.
Grant type:
ARC Discovery Projects
Researchers:

  • Dr Pranesh Padmanabhan

    NHMRC Emerging Leadership Fellow
    School of Biomedical Sciences
    Faculty of Medicine
    NHMRC Emerging Leadership Fellow
    Clem Jones Centre for Ageing Dementia Research
    Queensland Brain Institute

  • Professor Jürgen Götz

    Director of CJCADR - GL
    Queensland Brain Institute
Funded by:
Australian Research Council