Click chemistry to reveal how neurons and glia shape perineuronal nets (2023–2026)
Abstract:
The extracellular matrix (ECM) and its perineuronal nets (which are net-like structures with holes wrapped around
neurons) are largely underexplored, despite representing a remarkable 20% of the brain¿s total volume and having
been suggested to be involved in many brain functions. Interestingly, digestion of the ECM improves learning and
memory, but deficits return once the ECM has reformed. However, how this ECM remodelling is organised at a
cell-type level is not understood. Here we aim to close this knowledge gap, using cutting-edge technology
including bioconjugation and ultrasound-mediated cargo delivery. Together, this project aims to contribute to a
deeper understanding of this major brain compartment in neuronal function.