Glucocorticoid receptor-D1 modulates stress and inflammation (2023–2026)
Abstract:
Environmental stressors in mammalian pregnancy often cause inflammation in the mother which has an adverse
effect on the fetus and its survival. The current grant aims to examine the mechanism by which stress and
inflammation coexist in pregnancy because stress hormones normally exert anti-inflammatory actions. Contrary
to convention, a new glucocorticoid receptor (GR), GRalpha D1, is linked to increasing inflammation. Using
innovative molecular biology approaches, GRalphaD1's function will be examined to provide a deeper
understanding of how stress regulates inflammation in animal reproduction. The project aims to enhance
interdisciplinary collaborations with expected benefits including a paradigm shift in our knowledge in this field.