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Revealing bat antibody recognition mechanism against bat-borne viruses (2022–2025)

Abstract:
Bats act as asymptomic reservoir hosts for numerous zoonotic viruses that are lethal in humans, indicating that the bat immune system can control these viruses. However, little is known about bat immunity including how bat antibodies recognise bat-borne viruses. This project aims to study bat anti-viral antibodies by utilising innovative protein engineering, cutting-edge cryo-EM technology and single-cell isolation and sequencing. The project seeks to uncover bat-borne zoonotic virus glycoprotein architecture and reveal how bat antibodies function to inhibit viral infection. Expected outcomes will be new insight and tools to combat emerging and yet to emerge pathogens, enabling pandemic preparedness and increasing global biosecurity.
Grant type:
ARC Discovery Early Career Researcher Award
Researchers:

  • Dr Naphak Modhiran

    ARC DECRA Research Fellow
    School of Chemistry and Molecular Biosciences
    Faculty of Science
Funded by:
Australian Research Council