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Sulfoxide Polymers - A New Paradigm in Polymer Design (2021–2024)

Abstract:
Low fouling polymers are important for moderating interactions of molecules and particles with cells. In pharmaceutical sciences they are essential tools for extending the pharmacokinetics of dissolved drugs. However, the widely-used low-fouling polymer, poly(ethylene glycol) (PEG) has been recently reported to induce formation of anti-PEG antibodies. Polymeric alternatives to PEG are thus desperately needed. We introduce in this project super-hydrophilic polymers incorporating sulfoxide groups, mimics of the polar solvent DMSO. The project aims to explore how polymer architecture can enhance biocompatibility and reduce biofouling. The outcome will be a new class of low-fouling polymeric materials with broad application in the biosciences.
Grant type:
ARC Discovery Projects
Researchers:

  • Professor Andrew Whittaker

    Professorial Research Fellow and Se
    Australian Institute for Bioengineering and Nanotechnology
    Professorial Research Fellow and Se
    Australian Institute for Bioengineering and Nanotechnology
    Affiliate of Australian Research Co
    ARC Centre of Excellence-Green Electrochemical Transformation of Carbon Dioxide
    Faculty of Engineering, Architecture and Information Technology
    Affiliate Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science

  • Dr Changkui Fu

    NHMRC Emerging Leadership Fellow
    Australian Institute for Bioengineering and Nanotechnology
    NHMRC Emerging Leadership Fellow
    Australian Institute for Bioengineering and Nanotechnology
Funded by:
Australian Research Council