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Mobile DNA activity in the mammalian primordial germline (2021–2024)

Abstract:
Early in pregnancy, a handful of cells in the embryo become primordial germ cells (PGCs). These PGCs will eventually give rise to sperm or egg cells, representing a critical inter-generational genetic link. Mobile DNA sequences target PGCs to create new heritable genetic changes. This proposal aims to analyse the activity, regulation, and consequences of mobile DNA activity in PGCs. This project expects to generate significant knowledge about the origins of mammalian genetic diversity. Expected outcomes include enhanced national and international collaborations across disciplines and new experimental systems. The expected benefit is an enhanced understanding of the mutational processes underlying genetic diversity and disease in mammals.
Grant type:
ARC Discovery Projects
Researchers:

  • Dr Sandra Richardson

    NHMRC Emerging Leadership Fellow
    Mater Research Institute-UQ
    Faculty of Medicine

  • Dr Adam Ewing

    Honorary Associate Professor
    Mater Research Institute-UQ
    Faculty of Medicine
Funded by:
Australian Research Council