The University of Queensland

Visualising genetic mosaicism during development (2020–2023)

Abstract:

Genetic diversity is the variation in DNA sequence among individuals. We now know that there are also differences in the DNA sequences of cells within the same individual, known as genetic mosaicism. The aims of this proposal are 1) to develop a system to visualise genetic mosaicism 2) arising during embryonic development and 3) in the brain, driven by mobile DNA activity. The expected outcome of this proposal is an unprecedented understanding of the scope and consequences of mobile DNA-driven mosaicism. This work will have significant impacts in developmental genetics and neurogenetics, and has the benefit of introducing an innovative experimental system with the potential to spark international scientific collaboration and recognition.

Grant type:

ARC Discovery Projects

Researchers:

• 

  Professor Geoff Faulkner

  Professor in Neuroscience
  

  Queensland Brain Institute

• 

  Dr Sandra Richardson

  NHMRC Emerging Leadership Fellow
  

  Mater Research Institute-UQ

  Faculty of Medicine

Funded by:

Australian Research Council