How does brain stimulation modulate cortical processing and cognition? (2019–2023)
Electrical brain stimulation techniques have shown substantial promise as tools for studying the brain and behaviour. However, the physiological mechanisms through which stimulation alters neural activity - and thus behaviour - are unclear, and there is substantial variability in stimulation efficacy across individuals. The proposed project uses an innovative combination of stimulation and structural, functional, and neurochemical imaging to ascertain how stimulation affects the brain, and establish key factors predicting individual subjects' responsiveness. This will allow the development of protocols to increase stimulation efficacy, and advance understanding as to how the brain and behaviour are influenced by stimulation interventions.