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Automated high resolution & high contrast cryoTEM for 3D structural biology (2018–2019)

Abstract:
The aim of this proposal is to establish a frontier facility in automated single particle cryo-TEM and cryo-TEM tomography (Titan Krios) that will enable state-of-the-art atomic molecular structure research and 3D subcellular and cellular imaging for Australian scientists. It will span all multiscale cryo-TEM modalities from the visualisation of cells, membranes and macromolecular complexes, through to near-atomic resolution protein structure determination. With more than 200 new protein structures in 2016 achieved at 2-5Å resolution by the Titan Krios, cryo-single particle analysis and tomography are recognised as revolutionary technologies in molecular structural biology and powerful enablers of future ground-breaking discovery.
Grant type:
ARC Linkage Infrastructure, Equipment and Facilities
Researchers:

  • Professor Bostjan Kobe

    NHMRC Leadership Fellow
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliate Professor
    Institute for Molecular Bioscience

  • Professor Roger Wepf

    Director
    Centre for Microscopy and Microanalysis
    Director
    Pro-Vice-Chancellor (Research Infrastructure)

  • Professor Robert Parton

    ARC Laureate Fellow - Group Leader
    Institute for Molecular Bioscience
    ARC Laureate Fellow - Group Leader
    Institute for Molecular Bioscience
    Affiliate Professor
    School of Biomedical Sciences
    Faculty of Medicine

  • Professor Ben Hankamer

    Professorial Research Fellow
    Institute for Molecular Bioscience
    Professorial Research Fellow
    Institute for Molecular Bioscience
    Affiliate Professor of School of Ch
    School of Chemistry and Molecular Biosciences
    Faculty of Science

  • Associate Professor Michael Landsberg

    Associate Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science
    Affiliate Associate Professor
    Institute for Molecular Bioscience
    Affiliate of ARC COE for Innovation
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
Funded by:
Australian Research Council