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NHMRC-ARC Dementia Fellowship (Aus Based) - Discovering novel molecules that regulate axonal degeneration (2016–2021)

Abstract:
Axonal degeneration is a key early pathological hallmark of Alzheimer¿s disease and other dementias, and is a critical determinant of the development and progression of these diseases. Despite being described more than 100 years ago, we lack a basic understanding of the cellular and molecular mechanisms that regulate axonal degeneration, knowledge that is essential for the development of treatments and therapies for dementia and the preservation of healthy ageing. The overall goal of this project is to use the powerful genetic tools available in the model system C. elegans to discover and study the function of key molecules necessary to preserve axonal integrity and prevent degeneration. Focusing on a specific subset of sensory neurons and using a forward genetic approach, I have isolated novel mutants presenting axonal degeneration. Using genetic strategies and molecular biology techniques I aim to identify the defective genes and study their function. The proposed supervisor is a world expert in the field of axonal development, degeneration, and regeneration and the research environment offered in the Clem Jones Centre for Ageing Dementia research offers the best postdoctoral training in the field of dementia-related research within Australia. The innovative study proposed has the potential to make major discoveries that will allow a better understanding of the molecular mechanisms underlying such a fundamental aspect of Alzheimer¿s disease and related dementias.
Grant type:
NHMRC-ARC Dementia Research Development Fellowships Scheme
Researchers:

  • Dr Sean Coakley

    Senior Research Fellow
    School of Biomedical Sciences
    Faculty of Medicine
Funded by:
National Health and Medical Research Council