Niche regulation of normal and malignant stem cells (2016–2020)

Hematopoietic stem cells (HSC) reside in the bone marrow (BM) and make all the cells of the blood system. We study molecules in the BM regulating normal HSC to helping them survive chemotherapy. This means cancer patients should suffer less side-effects from their therapy. Some of these molecule also help leukaemia stem cells (LSC) resist chemotherapy. Inhibitors may a) reduce patient mortality caused by chemotherapy and b) sensitise LSC to chemotherapy enabling long-term cure.
Grant type:
NHMRC Research Fellowship
  • Honorary Associate Professor
    Mater Research Institute-UQ
    Faculty of Medicine
Funded by:
National Health and Medical Research Council