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The chemistry and biology of circular proteins (2015–2019)

Abstract:
The broad aims of this project are to exploit our competitive edge in plant-derived ultra-stable cyclic peptides to develop them for pharmaceutical and agricultural applications. It is based on discoveries made in our laboratory over the last 15 years and on our proposed development of innovative new methodologies for discovery, chemical synthesis and engineering of these molecules. The project is significant because it will contribute to high value biotechnology and agricultural industries in Australia. The major outcomes include fundamental new knowledge on the biosynthesis of circular proteins in plants, new approaches for their discovery and technologies of applying them as drug leads and agricultural products.
Grant type:
ARC Discovery Projects
Researchers:

  • Professor David Craik

    UQ Laureate Fellow - GL
    Institute for Molecular Bioscience
    UQ Laureate Fellow - GL
    Institute for Molecular Bioscience
    Centre Director of ARC COE for Inno
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
    Affiliate Professor of School of Bi
    School of Biomedical Sciences
    Faculty of Medicine

  • Dr Thomas Durek

    Senior Research Fellow
    Institute for Molecular Bioscience
    Senior Research Fellow
    Institute for Molecular Bioscience
Funded by:
Australian Research Council