Comparative toxicology of a fumigant and gasotransmitters: Testing a new model of fumigant toxicity in Caenorhabditis elegans (2014–2016)
- Abstract:
- Fumigants share physical, chemical and functional properties with a medically important class of signalling molecules called gasotransmitters. We propose that the toxicity of fumigants is directly caused by their ability to mimic and disrupt gasotransmitter signalling. We will test this hypothesis using the fumigant phosphine, a chemical that protects the vast majority of the world grain supply from insect pests. This work will show us what makes a fumigant toxic. This knowledge will facilitate the discovery and effective deployment of new fumigants.
- Grant type:
- ARC Discovery Projects
- Researchers:
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- Funded by:
- Australian Research Council
