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From Chemical Architecture to Protein Surfaces (2007–2009)

Abstract:
Proteins are essential molecules that define life, ageing, disease & death. They are polymers of amino acid building blocks which self-organize into highly flexible folded structures in water. In this program we are developing small molecules to structurally mimic small protein surfaces composed of peptide helices, strands, turns & their combinations. These new molecules will be shown to be structurally more stable, chemically more stable, more bioavailable, & cheaper to make than proteins, while exhibiting selected biological functions of proteins. The research has the potential to produce valuable new biological tools, drug & diagnostic leads, vaccines & nanomaterials that can significantly impact on science, medicine & industry.
Grant type:
ARC Discovery Projects
Researchers:

  • Professor David Fairlie

    NHMRC Leadership Fellow and Group L
    Institute for Molecular Bioscience
    NHMRC Leadership Fellow and Group L
    Institute for Molecular Bioscience
    Affiliate of ARC COE for Innovation
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
    of Institute for Molecular Bioscien
    Institute for Molecular Bioscience
Funded by:
Australian Research Council