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Smart Nanocapsules for Efficient Cellular Delivery of Bioactive Peptide Drugs (2007–2009)

Abstract:
We aim to develop and evaluate a novel class of peptide drug carriers for targeted cellular delivery. The project sets out to encapsulate bioactive therapeutic peptide drugs in biocompatible polypeptide nanocapsules (50-100 nm) with high loading, retained activity and in a free state via templating high surface area mesoporous silica (MS) nanoparticles and using layer-by-layer self-assembly technique. Successful carrying out this project will develop a practical synthesis technique for MS nanoparticles and an efficient encapsulation technique for various functional materials. This work is significant not only for constructing efficient site-specific drug delivery systems but also for the nanotechnology development in Australia.
Grant type:
ARC Discovery Projects
Researchers:

  • Professor Michael Yu

    Professorial Research Fellow & SGL
    Australian Institute for Bioengineering and Nanotechnology
Funded by:
Australian Research Council