The University of Queensland

Balancing cadherin-actin cooperation: the key regulatory role of Ena/VASP proteins (2006–2008)

Abstract:

Cell-cell interactions are fundamental determinants of tissue organization in health and disease. Cadherin cell-cell adhesion molecule cooperate with the actin cytoskeleton to control tissue patterning, yet the fundamental cellular and molecular mechanisms responsible for these actions are ill-understood. This project studies how different states of the actin cytoskeleton may be regulated by specific (Ena/VASP) proteins at cadherin contacts. It will probe how the balance between these different states may be regulated to control tissue pattterning.

Grant type:

ARC Discovery Projects

Researchers:

• 

  Professor Alpha Yap

  Professor and ARC Laureate Fellow
  

  Institute for Molecular Bioscience

Funded by:

Australian Research Council