The University of Queensland

Signalling cross-talk through Suppressors Of Cytokine Signalling (SOCS) initiates luteolysis in the ovary (2003–2005)

Abstract:

Members of the newly discovered SOCS protein family block cytokine signal transduction pathways, including those for prolactin and GH. We have discovered that one of these proteins, SOCS-3, is upregulated in the corpus luteum of the ovary by prostaglandins and propose that induction of prolactin or GH resistance is a hitherto unrecognised and critical step in luteolysis. We have also discovered that this cross-talk between prostaglandin- and cytokine-receptor signalling pathways occurs in preadipocyte and breast cell lines and propose that this research will serve as a paradigm for understanding how sensitivity to cytokines can be controlled at a molecular level.''

Grant type:

ARC Discovery Projects

Researchers:

• 

  Associate Professor Stephen Anderson

  Associate Professor
  

  School of Biomedical Sciences

  Faculty of Medicine

Funded by:

Australian Research Council