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Investigating the interaction of microRNAs-Wolbachia-Dengue virus in the mosquito vector, Aedes aegypti (2012–2015)

Abstract:
microRNAs are small non-coding RNAs, which are involved in regulation of almost all cellular processes from development to defense and pathogenesis. Their study is important in analyzing basic mechanisms of crosstalk between pathogens and hosts. In this project, we will investigate involvement of dengue mosquito vector (Aedes aegypti) miRNAs in interactions with an endosymbiont bacterium Wolbachia and inhibition of Dengue virus replication in mosquitoes. We will explore how miRNAs regulate expression of genes associated with descriptive phenotypes produced by Wolbachia. The outcomes will provide a solid foundation to design strategies in controlling a deadly vector and limit transmission of a medically significant virus.
Grant type:
ARC Discovery Early Career Researcher Award
Researchers:

  • Dr Mazhar Hussain

    Postdoctoral Research Fellow
    School of the Environment
    Faculty of Science
Funded by:
Australian Research Council