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Overcoming membrane protein research roadblocks: A Queensland facility for membrane protein production and crystallisation (2012–2013)

Abstract:
Membrane protein crystal structure determination is regarded as frontier research because of challenges in producing and crystallising these proteins. Our aim is to establish a unique facility in Queensland that will benefit Australian science by addressing these two roadblocks. Specifically we will enhance world-leading protein production and protein crystallography infrastructure already established in Queensland, by enabling large-scale expression of membrane proteins in a range of cell systems, and by implementing new membrane protein crystallisation and detection methods.
Grant type:
ARC Linkage Infrastructure, Equipment and Facilities
Researchers:

  • Professor Mark Schembri

    Professorial Research Fellow & Grou
    Institute for Molecular Bioscience
    Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science

  • Professor Bostjan Kobe

    NHMRC Leadership Fellow
    School of Chemistry and Molecular Biosciences
    Faculty of Science

  • Professor Matt Sweet

    NHMRC Leadership Fellow - GL
    Institute for Molecular Bioscience
    Affiliate NHMRC Leadership Fellow
    School of Chemistry and Molecular Biosciences
    Faculty of Science
Funded by:
Australian Research Council