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NHMRC Career Development Fellowship (Population Health; Level 2): Long term progression and pathways of cardiometabolic risks for mothers and their adult offspring (2012–2016)

Abstract:
My overall aims are for the Career Development Fellowship (CDF) (i) to develop a program of research to investigate long term postnatal outcomes of cardiovascular diseases (CVD) and mortality throughout the female reproductive life course and beyond, and (ii) to study the aetiology, progression and pathways of metabolic syndrome, diabetes, and obesity from birth to adulthood within adult males and females. Primarily I will use the Mater University Study of Pregnancy & Its Outcomes (MUSP) - a 30 year follow-up of 7223 mother-offspring pair started from early 1980s. I have already established my leadership within the MUSP, a nationally and internationally important study, specifically in the areas of obesity and cardiovascular risk, as well as several national and international collaborations and having securing several large NHMRC grants, I believe I have an ideal foundation and research support upon which to expand my existing research and embark on new directions for the next 4 years. From this ambitious research program, my expectations are twofold. Firstly, for mothers I aim to discover new knowledge concerning the impact of pregnancy related factors to later life cardiovascular risks and premature mortality, with the ultimate aim to prevent them. Secondly, for offspring, I will provide the evidence for targeting interventions aimed at reducing cardiovascular events and diabetes with subsequent quantifiable benefits for personal and population health. Finally, this research programme represents the efficient use of one of Australia's flagship epidemiological studies to extend understanding of the factors driving the obesity epidemic and its associated factors with the ultimate aim of being able to reverse this epidemic and improve public health.
Grant type:
NHMRC Career Development Award
Researchers:
Funded by:
National Health and Medical Research Council