NHMRC Career Development Fellowship (Level 2): Preventing complications of chronic obstructive pulmonary disease (2012–2017)

Abstract:
HYPOTHESES 1. Use of computed tomography coronary angiography (CTCA) identifies undetected, clinically important coronary artery disease in patients with COPD and reduces cardiac morbidity. 2. Biomarkers of immune and inflammatory responses can be used to predict severity and recurrence of COPD exacerbations. RESEARCH OBJECTIVES 1. Prevent cardiac complications: Determine the effectiveness of CTCA and appropriate cardiac management in reducing cardiac events in patients with COPD. 2. Prevent exacerbations: Correlate sputum, serum and geneetic biomarkers to severity and recurrence of acute exacerbations of COPD. STUDY 1: PREVENTING CARDIAC COMPLICATIONS OF COPD This RCT will test the benefit of CT coronary angiography (CTCA) in patients with COPD, to inform clinicians about the benefit of early detection of occult coronary artery disease as a complex comorbidity of COPD. Population: 300 patients with COPD, recruited during stability, during the first 2 years Intervention: CTCA, plus best practice care (n=150 COPD patients) Comparison: No CTCA, plus best practice care (n=150 COPD patients) Outcomes: Cardiac events during follow-up (2 years after recruitment) Design: Randomised controlled trial (RCT) STUDY 2: PREVENTING EXACERBATIONS OF COPD This cohort study will focus on characterising biomarkers (sputum, serum, genetic) to inform clinicians about severity and recurrence of COPD exacerbations. Population: 300 patients with COPD - recruited during exacerbations during the first 2 years Factors: Biomarkers predicting high risk and low risk of severity and recurrence of COPD Outcomes: Severity and recurrence of exacerbations Design: Prospective cohort study
Grant type:
NHMRC Career Development Award
Researchers:
  • Head, PCH North (Conjoint)
    Prince Charles Hospital Northside Clinical Unit
    Faculty of Medicine
    Head, PCH North Clinical (Conjoint)
    Medical School (Greater Brisbane Clinical School)
    Faculty of Medicine
Funded by:
National Health and Medical Research Council