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Cytoplasmic DNA as a danger signal for mammalian cells. (2010–2012)

Abstract:
DNA in mammalian cells is contained within a structure known as the nucleus. The presence of DNA outside the nucleus in the cytoplasm of the cells is a sure sign that something is wrong, and may indicate the presence of a viral invader. In this case the cell initiates anti-viral responses, including production of anti-viral proteins and death of the infected cell to stop replication of the virus. Lack of proper control of these responses may contribute to the autoimmune disease lupus.
Grant type:
NHMRC Project Grant
Researchers:

  • Professor Kate Stacey

    Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science

  • Professor Matt Sweet

    NHMRC Leadership Fellow - GL
    Institute for Molecular Bioscience
    Affiliate NHMRC Leadership Fellow
    School of Chemistry and Molecular Biosciences
    Faculty of Science
Funded by:
National Health and Medical Research Council