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Myosin VI: a novel molecular apparatus for epithelial cohesion. (2010–2012)

Abstract:
Adhesion between cells holds the human body together and affects many aspects of our health including normal tissue and organ function. Conversely, loss of normal cell-cell adhesion contributes to major diseases, including cancer and inflammation. One key molecule, E-cadherin, is necessary for many epithelial organs and its function is perturbed in disease. This research project addresses how E-cadherin works with a cellular motor, Myosin VI, to maintain the integrity of epithelial tissues.
Grant type:
NHMRC Project Grant
Researchers:

  • Professor Alpha Yap

    Professor and ARC Laureate Fellow
    Institute for Molecular Bioscience

  • Professor Brett Collins

    NHMRC Leadership Fellow - GL
    Institute for Molecular Bioscience

  • Professor Robert Parton

    ARC Laureate Fellow - Group Leader
    Institute for Molecular Bioscience
    Affiliate Professor
    School of Biomedical Sciences
    Faculty of Medicine
Funded by:
National Health and Medical Research Council