Epigenetic mechanisms regulating sex differences in fear-related learning and memory (2010–2014)
- Abstract:
- The overarching hypothesis of this proposal is that there are unique molecular mechanisms, which contribute to sex differences in learning and memory. The main aim is to determine how sexual-specific epigenetic mechanisms contribute to the formation and maintenance of long-term fear memories and to the extinction of conditioned fear. This will be accomplished by using a combination of state-of-the-art molecular techniques, genetics, pharmacology, viral-mediated gene transfer and well-established behavioural paradigms. These studies will bring us closer to understanding the role of the epigenome in mediating sex differences in fear-related learning and memory, and how they participate in anxiety disorders.
- Grant type:
- ARC Discovery Projects
- Researchers:
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- Funded by:
- Australian Research Council
