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Molecular mechanisms that help organise effective synaptic transmission. (2009–2012)

Abstract:
This study will test the idea that adhesion molecules alpha4- and beta2-laminin are needed for proper development and function of motor nerve - muscle connections. This study will provide insights into how such molecules control effective nerve-muscle communication, in both health and disease. We also believe that our results will provide the basic knowledge needed for identifying pharmacological targets that could improve such connections, and to promote reconnections between nerve and muscle.
Grant type:
NHMRC Project Grant
Researchers:

  • Associate Professor Peter Noakes

    Associate Professor
    School of Biomedical Sciences
    Faculty of Medicine

  • Professor David Craik

    UQ Laureate Fellow - GL
    Institute for Molecular Bioscience
    UQ Laureate Fellow - GL
    Institute for Molecular Bioscience
    Centre Director of ARC COE for Inno
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
    Affiliate Professor of School of Bi
    School of Biomedical Sciences
    Faculty of Medicine
Funded by:
National Health and Medical Research Council