The University of Queensland

AD A -induced cell death signalling by the p75 neurotrophin receptor. (2009–2011)

Abstract:

The amyloid peptide A is central to the cause of Alzheimer's disease. We have recently found that A can activate the cell death receptor p75NTR which is found in the nerve cells that die in Alzheimer's disease. This project will study whether this death pathway underpins the neuronal death associated with Alzheimer's disease. It will also determine the mechanism by which A activates p75NTR death signalling, and identify biochemical ways to prevent this from occurring.

Grant type:

NHMRC Project Grant

Researchers:

• 

  Professor Elizabeth Coulson

  Head of School
  

  School of Biomedical Sciences

  Faculty of Medicine

  Professor
  

  Queensland Brain Institute

Funded by:

National Health and Medical Research Council